Enfermedad de Still del Adulto. Revisión de la Literatura
Resumen
La enfermedad de Still, es una enfermedad sistémica de etiología desconocida, la cual tiene como principales características picos febriles, lesiones dermatológicas color salmón, artritis, odinofagia, hepatoesplenomegalia y en ciertos casos linfadenopatías. Algunos pacientes pueden presentar compromiso ocular, pulmonar, cardíaco, renal y del sistema nervioso. El diagnóstico se basa en datos clínicos y paraclínicos, los cuales, se han agrupado como criterios diagnósticos, propuestos en ocho diferentes escalas diagnósticas. Actualmente, el desarrollo de nuevos fármacos para el tratamiento de esta enfermedad ha sido posible gracias a los avances en el esclarecimiento de la fisiopatología, pero no se encuentran grandes series de estudios que apoyen o rechacen su uso en la práctica clínica, por lo que el pilar fundamental del tratamiento siguen siendo los corticoesteroides, antinflamatorios no esteroideos y los fármacos antirreumáticos modificadores de la enfermedad.
Palabras clave:
enfermedad de still, enfermedad de still del adulto, artritis idiopática juvenil sistémica
Texto completo:
Referencias
Agha-Abbaslou M, Bensaci AM, Dike O, Poznansky MC, Hyat A. Adult-onset still’s disease: Still a serious health problem (a case report and literature review). Am J Case Rep. 2017;18:119–24.
Liu Z, Lv X, Tang G. Clinical features and prognosis of adult-onset still’s disease: 75 cases from China. Int J Clin Exp Med. 2015;8(9):16634–9.
Hersh AO, Prahalad S. Immunogenetics of juvenile idiopathic arthritis: A comprehensive review. J Autoimmun. 2015;64:87–92.
Kadavath S, Efthimiou P. Adult-onset Still’s disease-pathogenesis, clinical manifestations, and new treatment options. Ann Med. 2015;47(1):6–14.
Mavragani CP, Spyridakis EG, Koutsilieris M. Adult-onset still’s disease: From pathophysiology to targeted therapies. Int J Inflam. 2012;2012:879020. doi: 10.1155/2012/879020.
Komiya A, Matsui T, Nogi S, Iwata K, Futami H, Takaoka H, et al. Neutrophil CD64 is upregulated in patients with active adult-onset Still’s disease.Scand J Rheumatol [Internet]. 2012;41(2):156–8. Disponible en: http://www.tandfonline.com/doi/full/10.3109/03009742.2011.644325
Fujii T. Cytokine and immunogenetic profiles in Japanese patients with adult Still’s disease. Association with chronic articular disease. Rheumatology [Internet]. 2001;40(12):1398–404. Disponible en: https://academic.oup.com/rheumatology/article-lookup/doi/10.1093/rheumatology/40.12.1398
Chen DY, Chen YM, Lan JL, Lin CC, Chen HH, Hsieh CW. Potential role of Th17 cells in the pathogenesis of adult-onset Still’s disease. Rheumatology [Internet]. 2010;49(12):2305–12. Disponible en: http://rheumatology.oxfordjournals.org/cgi/doi/10.1093/rheumatology/keq284
Chen DY, Lan JL, Lin FJ, Hsieh TY, Wen MC. Predominance of Th1 cytokine in peripheral blood and pathological tissues of patients with active untreated adult onset Still’s disease. Ann Rheum Dis [Internet]. 2004;63(10):1300–6. Disponible en: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1754751&tool=pmcentrez&rendertype=abstract
Rau M, Schiller M, Krienke S, Heyder P, Lorenz H, Blank N. Clinical manifestations but not cytokine profiles differentiate adult-onset Still’s disease and sepsis. J Rheumatol. 2010;37(11):2369–76.
Gopalarathinam R, Orlowsky E, Kesavalu R, Yelaminchili S. Adult Onset Still’s Disease: A Review on Diagnostic Workup and Treatment Options. Case Rep Rheumatol [Internet]. 2016;2016:1–6. Disponible en: http://www.hindawi.com/journals/crirh/2016/6502373/
Jamilloux Y, Gerfaud-Valentin M, Martinon F, Belot A, Henry T, Steve P. Pathogenesis of adult-onset Still ́s disease: new insights from the juvenile counterpart. Immunol Res. 2014;61(1–2):53–62.
Díaz P, Parra IH, Benavidez V, Caetano M, Reppel J, Aloise I. Enfermedad de Still del adulto: Diagnóstico a partir de las manifestaciones cutáneas. Med Cutan Ibero Lat Am. 2015;43(3):196–8.
Kikuchi N, Satoh M, Ohtsuka M, Yamamoto T. Persistent pruritic papules and plaques associated with adult-onset Still’s disease: Report of six cases. J Dermatol. 2014;41(5):407–10.
Castañeda S, Vicente EF, González-Gay MA. Enfermedad de Still del adulto. Med Clin (Barc) [Internet]. 2016;147(5):217–22. Disponible en: http://linkinghub.elsevier.com/retrieve/pii/S0025775316300665
Castañeda S, Blanco R, González-Gay MA. Adult-onset Still’s disease: Advances in the treatment. BestPract Res Clin Rheumatol [Internet]. 2016;30(2):222–38. Disponible en: http://linkinghub.elsevier.com/retrieve/pii/S1521694216300432
Sofía A, Avilés V, Elda R, Cobos B, Alejandro A, Rodríguez B, et al. Enfermedad de Still de inicio en el adulto. Rev Hosp Jua Mex. 2011;78(3):187-19018.
Kumar S, Kunhiraman D, Rajam L. Application of the Yamaguchi criteria for classification of “suspected” systemic juvenile idiopathic arthritis (sJIA). Pediatr Rheumatol [Internet]. 2012;10(1):40. Disponible en: http://pedrheum.biomedcentral.com/articles/10.1186/1546-0096-10-40
Mehta B, Efthimiou P. Ferritin in adult-onset still’s disease: Just a useful innocent bystander? (International Journal of Inflammation). Int JInflam. 2012;2012(January).
Gerfaud-Valentin M, Henry T, Séve P. Treatment of adult-onset Still’s disease: a review. Ther Clin Risk Manag. 2014;11:33–43. Published 2014 Dec 22. doi:10.2147/TCRM.S64951
Liu Z, Lv X, Tang G. Clinical features and prognosis of adult-onset still’s disease: 75 cases from China. Int J Clin Exp Med. 2015;8(9):16634–9.
Hersh AO, Prahalad S. Immunogenetics of juvenile idiopathic arthritis: A comprehensive review. J Autoimmun. 2015;64:87–92.
Kadavath S, Efthimiou P. Adult-onset Still’s disease-pathogenesis, clinical manifestations, and new treatment options. Ann Med. 2015;47(1):6–14.
Mavragani CP, Spyridakis EG, Koutsilieris M. Adult-onset still’s disease: From pathophysiology to targeted therapies. Int J Inflam. 2012;2012:879020. doi: 10.1155/2012/879020.
Komiya A, Matsui T, Nogi S, Iwata K, Futami H, Takaoka H, et al. Neutrophil CD64 is upregulated in patients with active adult-onset Still’s disease.Scand J Rheumatol [Internet]. 2012;41(2):156–8. Disponible en: http://www.tandfonline.com/doi/full/10.3109/03009742.2011.644325
Fujii T. Cytokine and immunogenetic profiles in Japanese patients with adult Still’s disease. Association with chronic articular disease. Rheumatology [Internet]. 2001;40(12):1398–404. Disponible en: https://academic.oup.com/rheumatology/article-lookup/doi/10.1093/rheumatology/40.12.1398
Chen DY, Chen YM, Lan JL, Lin CC, Chen HH, Hsieh CW. Potential role of Th17 cells in the pathogenesis of adult-onset Still’s disease. Rheumatology [Internet]. 2010;49(12):2305–12. Disponible en: http://rheumatology.oxfordjournals.org/cgi/doi/10.1093/rheumatology/keq284
Chen DY, Lan JL, Lin FJ, Hsieh TY, Wen MC. Predominance of Th1 cytokine in peripheral blood and pathological tissues of patients with active untreated adult onset Still’s disease. Ann Rheum Dis [Internet]. 2004;63(10):1300–6. Disponible en: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1754751&tool=pmcentrez&rendertype=abstract
Rau M, Schiller M, Krienke S, Heyder P, Lorenz H, Blank N. Clinical manifestations but not cytokine profiles differentiate adult-onset Still’s disease and sepsis. J Rheumatol. 2010;37(11):2369–76.
Gopalarathinam R, Orlowsky E, Kesavalu R, Yelaminchili S. Adult Onset Still’s Disease: A Review on Diagnostic Workup and Treatment Options. Case Rep Rheumatol [Internet]. 2016;2016:1–6. Disponible en: http://www.hindawi.com/journals/crirh/2016/6502373/
Jamilloux Y, Gerfaud-Valentin M, Martinon F, Belot A, Henry T, Steve P. Pathogenesis of adult-onset Still ́s disease: new insights from the juvenile counterpart. Immunol Res. 2014;61(1–2):53–62.
Díaz P, Parra IH, Benavidez V, Caetano M, Reppel J, Aloise I. Enfermedad de Still del adulto: Diagnóstico a partir de las manifestaciones cutáneas. Med Cutan Ibero Lat Am. 2015;43(3):196–8.
Kikuchi N, Satoh M, Ohtsuka M, Yamamoto T. Persistent pruritic papules and plaques associated with adult-onset Still’s disease: Report of six cases. J Dermatol. 2014;41(5):407–10.
Castañeda S, Vicente EF, González-Gay MA. Enfermedad de Still del adulto. Med Clin (Barc) [Internet]. 2016;147(5):217–22. Disponible en: http://linkinghub.elsevier.com/retrieve/pii/S0025775316300665
Castañeda S, Blanco R, González-Gay MA. Adult-onset Still’s disease: Advances in the treatment. BestPract Res Clin Rheumatol [Internet]. 2016;30(2):222–38. Disponible en: http://linkinghub.elsevier.com/retrieve/pii/S1521694216300432
Sofía A, Avilés V, Elda R, Cobos B, Alejandro A, Rodríguez B, et al. Enfermedad de Still de inicio en el adulto. Rev Hosp Jua Mex. 2011;78(3):187-19018.
Kumar S, Kunhiraman D, Rajam L. Application of the Yamaguchi criteria for classification of “suspected” systemic juvenile idiopathic arthritis (sJIA). Pediatr Rheumatol [Internet]. 2012;10(1):40. Disponible en: http://pedrheum.biomedcentral.com/articles/10.1186/1546-0096-10-40
Mehta B, Efthimiou P. Ferritin in adult-onset still’s disease: Just a useful innocent bystander? (International Journal of Inflammation). Int JInflam. 2012;2012(January).
Gerfaud-Valentin M, Henry T, Séve P. Treatment of adult-onset Still’s disease: a review. Ther Clin Risk Manag. 2014;11:33–43. Published 2014 Dec 22. doi:10.2147/TCRM.S64951
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